The research technician will be based in the laboratory of Russell Ryan in the University of Michigan Department of Pathology, and will assist in projects related to functional genomics and transcriptional regulation in lymphoid malignancies. The Ryan Lab will utilize cutting-edge tools for the genome-wide analysis of enhancer function and regulation in normal and malignant cell populations. Areas of focus include transcriptional regulation by Notch signaling in lymphoma, and enhancer-dependent regulation of MYC and other major lymphoma oncogenes.
- Biological research technician duties may include:
- Mammalian cell culture
- Basic molecular biology techniques (plasmid preparation, cloning, mutagenesis)
- Lentivirus production and use for genetic manipulation of cell lines
- Targeted genome editing or manipulation (CRISPR-Cas9 system)
- Chromatin immunoprecipitation of histone marks and transcription factors (ChIP-Seq)
- Next-generation sequencing library preparation and data production
- Retrieving and processing human lymphoma samples from tissue or blood.
- Other duties will include:
- Ordering, organizing and inventorying research equipment and materials
- Scientific and administrative record-keeping
- All work and data must be meticulously recorded and organized
- BA or BS, with a concentration in the biological sciences and 1-2 years of research laboratory experience (pre- or post-graduation) for the Senior level; HS diploma or an Associate's degree and a minimum of 1 year of experience for the Intermediate level
- Technically meticulous when conducting experiments
- Highly organized in record-keeping
- Strong communication and interpersonal skills
- Independent, intellectually passionate and able to display scientific initiative
- Experience in mammalian cell culture and basic molecular biology techniques strongly preferred
- The ideal candidate will be a highly motivated individual interested in a career in biological research or medicine
This position may be underfilled at a lower classification depending on the qualifications of the selected candidate.
Work will be performed at the Ryan lab, which will be established in July 2017. The lab will be primarily affiliated with the University of Michigan Department of Pathology, and will be located in the Life Sciences Institute in the U-M Central Campus. As a new laboratory, some of our initial projects will be conducted in collaboration with established labs in the Department of Pathology and the Life Sciences Institute at U-M, as well as with off-site collaborators at Massachusetts General Hospital, Brigham and Women’s hospital, the University of Pennsylvania, and the Broad Institute.
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Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.
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The University of Michigan is an equal opportunity/affirmative action employer.