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How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Job Summary

The Life Sciences Institute (LSI) at the University of Michigan is seeking a Cryo-EM specialist to assist in the daily operation of a well-established, state-of-the-art Electron Microscopy Facility.  This facility houses a Titan Krios and Talos Arctica, each equipped with K2 Summit direct detector. It also includes a Technai T12 dedicated for negative stain image collection, and Morgagni for negative stain sample screening. The Cryo-EM specialist will work closely with the facility director in order to perform tasks within demanding deadlines and ensure accurate logs.


Responsibilities will include but not be limited to the following:

  • Monitor and assist maintaining electron microscopes and related peripheral equipment

  • Coordinating and reporting equipment problems to the OEM and facility users

  • Prepare sample grids for negative stain and Cryo-EM imaging

  • Collect data on the electron microscopes using automated image acquisition software tools

  • Participate in image analysis and data processing

  • Train users in sample preparation and data collection

  • Provide consultation for researchers to improved data acquisition or sample preparation

  • Establish and improve equipment operation protocols

Required Qualifications*

  • Bachelor’s degree in Biology, Biochemistry, Biophysics or a related field

  • Minimum 2 years of hands on experience in Cryo-EM

  • Knowledge of principles of transmission electron microscopy

  • Solid understanding of single particle approach, Cryo electron tomography is a plus

  • Basic computer skills in Linux operating systems

  • Excellent communication and interpersonal skills with a strong customer service focus and demonstrated commitment to creating a positive work environment

  • Highly organized, attentive to detail and accuracy, and strong record-keeping skills are essential

  • Demonstrated ability to successfully interact with diverse groups of faculty, staff and students 

  • Demonstrated ability to work collaboratively in a team environment as well as independently

  • Experience in providing instruction/training to others

  • Proven ability to adapt as priorities shift

  • Demonstrated ability to set priorities, multi-task, handle multiple assignments and meet deadlines, and display excellent judgment while operating in a flexible and professional manner

Desired Qualifications*

  • Master’s or Ph.D. in Biology, Biochemistry, Biophysics or a related field

  • Minimum of 3-5 years hands-on experience in Cryo-EM

  • Prior experience working in an academic research setting

Underfill Statement

This position may be underfilled at a lower classification depending on the qualifications of the selected candidate.

Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks will be performed in compliance with the Fair Credit Reporting Act.

Application Deadline

Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.