The laboratory of Dr. Russell Ryan in the University of Michigan Medical School Department of Pathology is seeking a highly motivated postdoctoral fellow for advanced training in the field of epigenomics, transcriptional regulation, and cancer biology. Our goal is to deconstruct the functional inputs that control expression of major oncogenes in B-cell lymphoma, with a particular focus on distal regulatory elements and therapeutically targetable upstream pathways.
The successful applicant will work with the PI to design and advance a project with the dual goals of advancing the lab’s research program and building the applicant’s capabilities as an independent scientist. Models will include cancer cell lines, primary human cells and tissues (including clinically obtained samples), and mouse models, depending on the nature of the project and the fellow’s prior experience. Methodologies may include the use of epigenomic and genome topology mapping assays (ChIP-Seq, ATAC-Seq, 4C-Seq), large-scale pooled screens, including CRISPR-Cas9-based approaches, and computational analysis of next-generation sequencing datasets. The fellow must be able to work collaboratively and will supervise and mentor junior colleagues as part of their career development.
Applicants should possess a Ph.D. in a related field, with a record of relevant research experience and should demonstrate excellent oral communication and scientific writing skills. Candidates with experience in the analysis of next-generation sequencing datasets will be preferred.
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