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Job Summary

The successful candidate will conduct research, under the supervision of Dr. Segal, on the following topics: (i) the pathogenic versus beneficial effects of neuroinflammation in a variety of mouse models, including models of multiple sclerosis (MS) and central nervous system (CNS) trauma, (ii) biomarker studies of individuals with MS or other neurological disorders compared with healthy controls, (iii) mechanistic substudies of clinical trials in MS.  The candidate will be expected to independently manage research projects, train and supervise laboratory staff, students and fellows, as well as assist in the writing of manuscripts, progress reports, protocols, and grant proposals.


The successful candidate will oversee and assist in the conduct of a variety of research projects in a Neuroimmunology Laboratory, spanning animal model and clinical studies.  Ongoing projects involve the roles of leukocyte subsets and cytokine/ chemokine pathways in animal models of MS, the response of CNS resident glial cells to neuroinflammation in models of MS and other CNS disorders, the mechanisms underlying immune driven axon regeneration in optic nerve crush and spinal cord injury models,  biomarker discovery using clinical specimens from patients with MS and other neurological disorders, and mechanistic studies of disease modifying therapies in MS.  The successful candidate will be expected to manage multiple collaborative projects with laboratories inside and outside the institution, optimize and validate experimental protocols, assist in the writing of manuscripts, progress reports, and grant applications, prepare and update UCUCA and IRB applications/ protocols, perform power calculations and statistical analyses of complex data sets, ensure lab documentation is up to date for safety inspections, operate, maintain and calibrate instrumentation and research equipment (including a BD FACSCanto II flow cytometer and Zeiss Axio Observer), make minor repairs to research equipment, manage a weekly data/ journal club, plan and coordinate the work of lab assistants and entry level research staff, and train or supervise postdoctoral fellows, graduate students, undergraduates and more junior technicians.

Required Qualifications*

Bachelors of Science degree and 4-5 years of experience.  The candidate should have experience handling mice.  He or she should have experience with flow cytometry, immunohistochemistry, cell culture, genotyping, immunohistochemistry, and molecular biology techniques. 

Desired Qualifications*

  • MD or PhD degree in related field
  • 6 years of laboratory experience
  • experience in advanced immunological techniques
  • experience preparing UCUCA and IRB protocols/ amendments

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Application Deadline

Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.