Our research aims to take advantage of endogenous stem cells to regenerate a damaged central nervous system. We use the zebrafish retina as a model system because it exhibits a very robust regenerative response to nerve cell ablation.
We seek a recent PhD that is highly motivated, bright and creative to join our group and to help further characterize mechanisms underlying retina regeneration in zebrafish. We are using RNAseq, ATACseq, CRISPR/Cas9, transgenic and other molecular and cellular approaches to identify the mechanisms by which zebrafish regenerate a damaged retina. In addition, we are using live transgenic zebrafish that report retina regeneration in large scale screens to identify small molecules that stimulate the regenerative process. Factors stimulating retina regeneration in fish will be applied to mice to determine if retina regeneration can be stimulated in a mammalian model. Research Fellows are expected to work independently and in teams; design and implement new research strategies; collect and analyze data; and write research manuscripts for publication.
Ph.D. in neuroscience, biology, or related discipline. Publications demonstrating research experience and productivity. Proficient in the techniques of molecular and cellular biology
A recent Ph.D. in neuroscience or related biological discipline. Experience working with mouse and/or fish animal models. Previous research studying neural development, retina, regeneration, and/or stem cells.
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