How to Apply
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A post-doctoral position is available in the CHaR (Cartilage Healing and Regeneration) lab in the Department of Biomedical Engineering at the University of Michigan. The project’s focus is to test the ability of synthetic gene circuits to regulate the maturation of chondrocytes and chondrogenic stem cells to regenerate articular cartilage in a rodent model. We have successfully engineered a circuit that responds to transcription factor activity in progenitor cells. A highly motivated applicant will work with a team of graduate students to examine how this circuit directs chondrogenic tissue generation by both stem cells and chondrocytes in vitro, and articular cartilage repair in cartilaginous defects in vivo. This is a novel and rapidly growing area at the forefront of tissue regeneration. The successful applicant will have the opportunity to make a significant impact in this field.
Techniques to be performed include PCR real time, Nucleic Acid Extraction and Purification, sub-cloning of plasmid vectors, DNA and protein electrophoresis, Western blotting, standard biochemical assays (ELISAs, extracellular matrix quantification), histology, and small animal surgery. Prior rodent husbandry and surgery experience is preferred. The applicant will learn how features of a gene circuit affect transduced cell functions critical to matrix generation and tissue repair, in both diseased primary cells (chondrocytes from osteoarthritic patients) and stem cells.
Ph.D. in Biomedical Engineering, Life Sciences, or related fields. Applicants with the skills in designing and performing mammalian cell culture experiments and tissue engineering techniques, as well as extensive experience in molecular biology, and small animal handling are preferred.
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U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.