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How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.  Please submit to:  rhimacol@umich.edu.

Job Summary

A post-doctoral position is available in the CHaR (Cartilage Healing and Regeneration) lab in the Department of Biomedical Engineering at the University of Michigan. The project’s focus is to test the ability of synthetic gene circuits to regulate the maturation of chondrocytes and chondrogenic stem cells to regenerate articular cartilage in a rodent model. We have successfully engineered a circuit that responds to transcription factor activity in progenitor cells. A highly motivated applicant will work with a team of graduate students to examine how this circuit directs chondrogenic tissue generation by both stem cells and chondrocytes in vitro, and articular cartilage repair in cartilaginous defects in vivo. This is a novel and rapidly growing area at the forefront of tissue regeneration. The successful applicant will have the opportunity to make a significant impact in this field. 

Responsibilities*

Techniques to be performed include PCR real time, Nucleic Acid Extraction and Purification, sub-cloning of plasmid vectors, DNA and protein electrophoresis, Western blotting, standard biochemical assays (ELISAs, extracellular matrix quantification), histology, and small animal surgery. Prior rodent husbandry and surgery experience is preferred. The applicant will learn how features of a gene circuit affect transduced cell functions critical to matrix generation and tissue repair, in both diseased primary cells (chondrocytes from osteoarthritic patients) and stem cells.

Required Qualifications*

Ph.D. in Biomedical Engineering, Life Sciences, or related fields.  Applicants with the skills in designing and performing mammalian cell culture experiments and tissue engineering techniques, as well as extensive experience in molecular biology, and small animal handling are preferred.

Additional Information

Michigan Engineering’s vision is to be the world’s preeminent college of engineering serving the common good. This global outlook, leadership focus and service commitment permeate our culture. Our vision is supported by a mission and values that, together, provide the framework for all that we do.  Information about our vision, mission and values can be found at: http://strategicvision.engin.umich.edu/ .

The University of Michigan has a storied legacy of commitment to Diversity, Equity and Inclusion (DEI). The Michigan Engineering  component of the University’s comprehensive, five-year, DEI strategic plan—along with updates on our programs and resources dedicated to ensuring a welcoming, fair and inclusive environment—can be found at: http://www.engin.umich.edu/college/about/diversity 

Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks.  Background checks will be performed in compliance with the Fair Credit Reporting Act.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  This job may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.