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Please include a cover letter stating your research experience, interests, and future plans along with a CV or resume; please include contact information for references.
The Meisler laboratory in the Department of Human Genetics at the University of Michigan Medical School is seeking a postdoctoral fellow to join a group working on the genetic basis of neurological disorders, with a current focus on epilepsy. We are studying the mechanisms by which mutations in sodium channel genes result in seizures in patients with epileptic encephalopathy. More than 100 mutations have been identified in the SCN8A gene, resulting in gain-of-function changes in the biophysical properties of the channel and neuronal hyperactivity. We generated two mouse models of patient mutations in order to probe disease mechanisms and test therapies. The conditional mouse model enables us to dissect pathogenesis in different classes of neurons at different stages of development. We are interested in the role of somatic mutation in the development of epilepsy, and we are also beginning a program in gene therapy for inherited seizure disorders. Projects involve assessment of molecular and behavioral effects in vivo as well as characterization of new patient mutations. The lab includes six full time scientists and several undergraduates. The Department of Human Genetics provides a stimulating intellectual environment with an active seminar program and opportunities to participate in advances in this dynamic field.
Pursue full-time research into molecular mechanisms of neurological disease; read deeply in the relevant scientific literature; attend seminars and participate in joint lab meetings with other groups in Human Genetics; prepare manuscripts for publication and present research at national meetings.
Ph. D. in biomedical science, with a background in neuroscience preferred. Strong intellectual committment to understanding molecular mechanisms. Enthusiasm for research.
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