How to Apply
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
To be responsible for oversight of and technical contribution to in vitro and in vivo vertebrate animal experiments and related scientific projects in a cancer biology research laboratory. Will function as a skilled specialist in project(s) that involve isolation and genetic modification of primary murine cells and of human cell lines, as well as drug/ molecular/cellular/tumor biology studies of various models; and will contribute to project coordination, grant and manuscript writing.
- Design, Perform and interpret studies of signaling axes in cell and tumor models with focus on developmental pathways (Wnt, Hox), TGF-beta signaling, and the tumor microenvironment
- Perform and oversee in vivo tumorigenicity assays in murine models – subcutaneous, tail vein and bone xenografts models in immune deficient mice as well as genetic models in immune competent mice
- Drug dosing and tumor and toxicity monitoring in murine models
- Genotyping and colony management
- Small animal imaging – IVIS, xRay
- Necropsy & tissue dissection/fixation
- Tissue preparation for molecular, biochemical and histologic studies
- Monitor integrity of data collection and use of protocols and procedures
- Write and collaborate with other researchers on manuscripts, abstracts, technical reports and other publications of research findings
- Provide instruction and technical support to academic trainees in the lab
- Develop, design, and conduct more complex experiments in line with a research plan and review results periodically with faculty member or senior research staff member
- Maintain and update IACUC protocols
- Direct day-to-day lab operations such as equipment maintenance and lab supply ordering
- Coordinate the collection and analysis of data and the conduct of experimental procedures
- Bachelor’s Degree and at 4-5 years of relevant laboratory experience
- Demonstrated excellence and proven competency in molecular, cellular, and tumor biology
- Demonstrated excellence and proven competency in establishing and monitoring murine tumor models
- Proficiency with in vivo drug dosing and toxicity studies, blood collection, euthanasia, IP injections, and other standard murine-based procedures
- Experience with mammalian cell culture
- Excellent interpersonal and organizational skills
- Excellent written and oral communication skills
- Demonstrated ability to teach and/or train students, junior laboratory personnel in laboratory techniques and/or protocols
- Ability to work independently and as a member of our team
- Excellent attendance, ability to prioritize appropriately, and exercise good judgment
- Master’s or PhD in cancer biology or discipline related to the position
- Experience with primary cell isolation and culture
- Familiarity with University research administration, policies and procedures especially those related to IACUC and ULAM
Evidence of qualifications is provided by previous employment, reference checks, performance evaluations and/or personal interview
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.