How to Apply
A cover letter is required for consideration of the position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The names, institutions, phone numbers and email addresses should be provided for three (3) professional references.
Research Laboratory Technician Senior - RE130 - is available at the University of Michigan in the ‘Integrative Molecular Genetics Laboratory’ (http://www.kines.umich.edu/research/imgl) within the School of Kinesiology at the University of Michigan (Lab Director: Andrew T. Ludlow, Ph.D.). The current general research objective of the Integrative Molecular Genetics Laboratory is to elucidate the mechanisms of how telomere length and telomerase/hTERT is regulated in stem cells, normal cells, and cancer cells and in response to physiological stressors. The successful applicant will provide knowledge and experience with RNA biochemistry, molecular biology (western and southern blotting, cloning, transformation, PCR, reverse transcriptase PCR), mammalian tissue/cell culture techniques, and small animal experiments. These skills will be utilized on a variety of projects related to the regulation of hTERT alternative splicing and will compliment ongoing projects in the laboratory. The goal of the research is to understand the molecular and contextual (i.e., cell state/type) regulation of human telomerase reverse transcriptase component (hTERT). These hypotheses will be tested in a variety of model systems including mammalian tissue culture and rodent models.
The individual will be responsible for leading discrete components of a larger research project. S/he will work with the PI to design experiments that the candidate will conduct, often in collaboration with other lab members. The individual will perform analysis of biological samples including cultured cells from a wide variety of human and rodent culture models and rodent tissues. Laboratory procedures will include, but not be limited to, sample processing, e. coli based molecular cloning and transformation, western blotting, PCR, enzyme activity assays, dissection, and southern blotting. The individual will need to assist and perform xenograft experiments and rodent physiological experiments. S/he will need to be able to work with the PI and other lab members to modify or devise biochemical methods, as needed. S/he will need to maintain research databases and perform basic statistical analyses of data.
- The individual should have a B.S./B.A.
- Degree or equivalent in a biological science with at least one year of experience in a biological research laboratory.
- The candidate must be honest and dependable and have a high level of motivation and technical skill in biochemistry, with experience or interest and ability to apply these methods to animal physiology.
- Proficiency in PCR, cloning, and mammalian tissue culture is required.
- Willingness and ability to trouble-shoot new methods is important.
- Performance of research using rodent research models is also required.
- S/he will need to be willing and able to learn new methods as needed.
- Fluency in written and spoken English and the ability to work as part of research team are essential.
- The successful candidate will be able to work independently and as a member of a research team.
- Must be able and willing to occasionally work on weekends.
This is a one-year term limited position with the potential to extend for up to two years based on funding and successful performance in the role.
Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.