How to Apply
Please include a cover letter stating your research experience, interests, and future plans along with a CV or resume. Please be sure to also include contact information for references.
The Kalantry Laboratory in the Department of Human Genetics at the University of Michigan Medical School is seeking a postdoctoral fellow to join a group working on genetically dissecting the epigenetic basis of X-chromosome inactivation. X-inactivation is an evolutionarily conserved process that equalizes X-linked gene expression between male and female mammals by silencing genes on one of the two X-chromosomes in females. Once inactivated, replicated copies of the X-chromosome are maintained as inactive throughout future rounds of cell division, making X-inactivation a paradigm of epigenetic inheritance. X-inactivation lies at the nexus of functional long non coding (lnc) RNAs and chromatin-modifying factors. Our lab has discovered new lncRNAs and identified chromatin modifying proteins with a previously unknown function in X-inactivation. Projects involve functionally interrogating these lncRNAs and chromatin modifiers and their relationship in causing X-inactivation via both high- and low-throughput assays in cultured stem cells and in mice. The lab is currently comprised of five full-time scientists and has room for up to three new post-doctoral/graduate trainees. The Department of Human Genetics provides a stimulating intellectual environment with an active seminar program and opportunities to participate in advances in chromatin biology and beyond. See our lab website (http://www-personal.umich.edu/~kalantry/Kalantry_Lab/Welcome.html) and the Department of Human Genetics website (https://medicine.umich.edu/dept/human-genetics) for more information.
Pursue full-time research into epigenetic mechanisms underlying X-chromosome inactivation; read deeply in the relevant scientific literature; attend seminars and participate in joint lab meetings with other groups in Human Genetics; prepare manuscripts for publication and present research at national meetings.
Ph.D. in biomedical science. Strong intellectual commitment to understanding molecular mechanisms. Enthusiasm for research.
A background in chromatin biology and/or embryology and/or stem cell biology preferred.
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