The Castro Laboratory in the Department of Neurosurgery and the Department of Cell and Developmental Biology is accepting applications for a Research Fellow. The successful candidate will join an exciting and productive research team focused on elucidating the molecular mechanisms that mediate innate immunity in mutant IDH1 gliomas, the reprograming of the tumor microenvironment and the response to novel immune-based therapeutics. The project studies the epigenetic mechanisms within the immune microenvironment with special emphasis on histone and DNA level methylation patterns. The project also has a strong translational component to develop and implement novel therapeutics in human clinical trials for brain cancer; these include gene therapy strategies, bromodomain inhibitors, epigenetic modulators, small molecules and nanotechnologies. The lab is utilizing several different types of gene therapy and exploring ways to translate the research into novel therapies for adult and pediatric brain tumors.
The applicant will play an active role in the design, execution and outcome assessment of the research study. The successful applicant will develop and conduct more complex experiments related to the epigenetic analysis of histone and DNA marks, coupled to next generation sequencing and bioinformatics analysis. He/she will provide input into the development of procedures and research design, and review results with supervisors. The selected candidate will be responsible for accurate scientific research, documentation of results and evaluation/analysis of data. The applicant will provide laboratory support and keep accurate records of laboratory plasmid, bacterial and cell stocks. He/she will also contribute to the preparation of grants to NIH and foundations under the supervision of Dr. Castro, and will compile information for posters, abstracts, papers and reviews. Participation in weekly lab meetings, including presentation of data, is required.
PhD in Chemistry or Biochemistry and 3-5 years of experience in a research laboratory. Knowledge of bioinformatics analysis, including analysis of RNA-seq, ChIP-seq of specific histone marks and BrU-seq data. Experience conducting experiments independently or with supervision and with a broad spectrum of laboratory techniques such as ChIP-seq, Bru-seq, RNA-seq, bioinformatic analysis tools, small molecule design and small molecule library screening, molecular biology, immunocytochemistry, transfection, cell culture, neurosurgery techniques in rodents, confocal microscopy, in vivo delivery of gene transfer platforms into the brain, qPCR, cytokine array and ELISA. Excellent decision making and the ability to assume a substantial portion of the research project work. Must have excellent written and oral communication skills, and knowledge of Microsoft Office including PowerPoint, GraphPad Prism and relevant statistical analytical tools, and Adobe PhotoShop and Illustrator.
A strong work ethic and the ability to work independently combined with a willingness to work in a highly interactive and collegial environment.
This position is anticipated to begin in October of November of 2018
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