How to Apply
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The Center for Structural Biology, (CSB) within the Life Sciences Institute at the University of Michigan, seeks a post-doctoral candidate with crystallography experience, who is interested in developing cutting edge purification and crystallization technologies for RNA and RNA-Protein complexes. The Center for Structural Biology acts as the structural biology core for the Center for HIV RNA Studies (CRNA), which is a large consortium of researchers across the nation focusing on the structures, dynamics, interactions, and mechanisms of action of the HIV-1 RNA during the late phase of viral replication. Funding for these studies is provided by the National Institutes of General Medical Sciences, National Institutes of Health.
The Center includes:
- A high-throughput cloning and expression laboratory for protein engineering
- Protein expression and purification facilities for small- and large-scale protein production
- Macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules
- X-ray facilities with membership access to high energy synchotron radiation (LS-CAT beam-lines at the Argonne National Laboratory)
- The development of an RNA production facility
The Post-doctoral fellow will work under the direction of Jeanne A. Stuckey, Ph.D, Managing Director of CSB and Research Associate Professor, and work in collaboration with members of the CRNA and CSB.
The successful candidate will apply their energy and expertise to cutting edge science and drug discovery by:
- Cultivate large-scale growths of bacteria and purify proteins for crystallographic studies
- Establish and modify recombinant DNA constructs for protein expression
- Establish and purify RNA constructs
- Perform crystallization experiments, data collection and refinement of x-ray structures
- Maintain laboratory stocks of buffers and competent cells
- Aid in coordinating projects on schedule
- Designing and executing experiments in collaboration with others.
- Initially work under the supervision of current CSB staff with the expectation of developing independence
- Maintain clear laboratory notebooks, perform quantitative analyses, and communicate findings through reports and summaries.
- Provide detailed documentation so experiments can be replicated.
- Follow laboratory best practices for safety and quality.
- Have excellent verbal and written communication skills
- Ph.D. in structural biology, biophysics, biochemistry or related discipline as well as relevant experience in protein crystallography.
- High degree of motivation and the ability to think independently and work collaboratively
- Excellent verbal and written communication skills
- Experience with protein purification techniques
- Experience in protein crystallography
- Experience in the field of RNA
- Experience with assay development
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks will be performed in compliance with the Fair Credit Reporting Act.
Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.