How to Apply
Interested applicants should email Dr. Karl Desch directly at firstname.lastname@example.org with a cover letter describing research experiences and interests, curriculum vitae, and contact information for three letters of reference.
The laboratory of Dr. Karl Desch at the University of Michigan is seeking a postdoctoral fellow to study the functional consequences of mutations identified in the STAB2 gene and the molecular mechanisms leading to increased risk of thrombosis in humans.
The work in our lab addresses a deficiency in our field relating to the lack of a functional understanding of genetic associations. The lab is concentrating on projects to characterize the functional consequences of common and rare variants in genes associated with bleeding or thrombosis risk. This work is informed by recent genomic studies of hemostasis related biochemical traits in a large cohort of healthy University of Michigan students and in collaboration with large clinical trials in patients with venous thrombosis. Our lab utilizes core molecular and cellular biology techniques such as Gibson assembly, stable cell line selection, western blotting, confocal microscopy and flow cytometry. We are using current techniques such as proximity labeling, next generation sequencing, saturating mutagenesis screens, whole genome CRISPR screens as well as lentiviral transduction.
We are looking for a highly motivated and ambitious scientist with a doctoral degree in a biological science discipline. The successful candidate is expected to conduct research independently under the supervision of the PI. Prior experience in basic molecular and cellular biology is required. Applicants with expertise in areas including but not limited to, imaging, flow cytometry, protein-protein interactions are preferred.
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