The research theme in Dr. Holoshitz' laboratory involves mechanisms of autoimmune diseases. Using cellular, molecular, signal transduction, protein chemistry, systems biology, bioinformatics and drug design strategies, the laboratory is focusing on understanding the molecular mechanisms in autoimmune diseases, with an ultimate goal of developing novel treatments.
The position posted here for an NIH-funded Research Lab Tech Lead position seeks to attract a motivated and skilled individual who is excited about exploring new mechanisms of autoimmune diseases, which could open the door to new therapies.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
- Laboratory management/supervision, ordering laboratory reagents and supplies, and keeping the laboratory stocked at all times
- Oversee compliance (IACUC, Hazardous materials, etc.). Maintain OSEH safety requirements and documentation in the lab
- Help to oversee and maintain condition and cleanliness of the lab, including instrument maintenance- Coordinate service when necessary
- Administrative duties such as overseeing and keeping records of laboratory purchases; coordinating with Principal Investigator on budgetary issues
- Assist in the development of laboratory policies and procedures
- Aid in maintaining animal colony, including some breeding, tagging, tailing, and genotyping. Import and shipping of rodent strains and other reagents
- Maintain laboratory documentation for experimental analysis
- Perform independent research, keep accurate records of experiments, analyze data for publication, and present results to Principal Investigator
- Execute, develop and improve assays such as RT-qPCR, in vitro transcription, immunoblotting and ELISAs
- Assist in the implementation of new molecular techniques and bioassays in the laboratory
- Provide assistance with the training and supervising of students as well as other support personnel in molecular and cellular biology
- Participate in laboratory meetings and journal clubs
- Provide technical support according to overall project goals as developed by the Principal Investigator
- Work in collaboration with Principal Investigator on other projects as needed
- Bachelor's degree in biochemistry, biology, molecular biology, or related health science field
- 2 to 3 years of experience in basic laboratory research and a demonstrated ability to execute the duties described above
- Excellent interpersonal, communicative, and computer skills, as well as the demonstrated ability to work with others in a collaborative environment are a must
- Experience in mouse research, performing cell culture, RT-qPCR, immunoblotting and ELISAs
- Willingness to be trained in new laboratory techniques as appropriate to the scientific findings
May be required to work in the evenings and weekends as needed to maintain on-going experiments.
- Master’s degree in molecular biology, integrative physiology, pharmacology, or related health science field
- Previous experience designing and/or performing RNA-sequencing experiments is highly desirable
- Experience in experimental mouse models of arthritis
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Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.
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The University of Michigan is an equal opportunity/affirmative action employer.