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A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Job Summary

About the Life Sciences Institute:

The Life Sciences Institute (LSI) is a multi-disciplinary research institute at the University of Michigan, strategically located as a bridge between the medical campus and the central-campus schools and colleges. Our mission is to advance the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health.

The LSI’s world-class faculty members hold joint appointments at the LSI, where their labs are located, and a variety of schools and colleges across the university. They bring broad and diverse expertise — ranging from cell biology to medicine, from chemistry to structural biology. The institute’s philosophy is to provide our faculty and their teams with superior scientific tools and administrative support, allowing them to spend more time focused on what really matters — their research.

The institute’s administrative staff supports all aspects of unit operations including facilities, IT, human resources, finance, research administration, academic programs, communications and development.  

In addition to faculty labs, the LSI houses several core technology labs that support the research enterprise of the entire university, including a high-throughput screening center (Center for Chemical Genomics), a comprehensive cloning and macromolecular X-ray crystallography facility (Center for Structural Biology), a comprehensive microbial biodiversity fermentation and metabolite analytics facility (Natural Products Discovery Core) and a state-of-the-art cryo-electron microscopy facility. The LSI also plays a key role in administering campus-wide programs like the U-M Program in Chemical Biology, Michigan Drug Discovery, and Michigan Life Sciences Fellows.

The LSI is committed to the principle that fostering diversity, equity and inclusion within the institute — and in the next generation of scientific leaders — is inseparable from our commitment to scientific excellence and achievement.

Position Summary:

The University of Michigan is seeking a Cryo-EM specialist to assist in the daily operation of a well-established, state-of-the-art Electron Microscopy Facility. This facility houses a Titan Krios and Talos Arctica, each equipped with K2 Summit direct detector and a Glacios equipped with a Falcon3 direct detector. It also includes a Technai T12 dedicated for negative stain image collection, and Morgagni for negative stain sample screening. The Cryo-EM specialist will mainly be responsible for training users, vitrifying samples, loading grids, and taking images on the 200 kV Glacios and will work closely with the facility directors in order to perform tasks within demanding deadlines and ensure accurate logs.


Responsibilities will include but not be limited to the following:

  • Monitor and assist maintaining electron microscopes and related peripheral equipment
  • Coordinating and reporting equipment problems to the OEM and facility users
  • Prepare sample grids for negative stain and Cryo-EM imaging
  • Collect data on the electron microscopes using automated image acquisition software tools
  • Train users in grid preparation and data collection
  • Provide consultation for researchers to improve data acquisition
  • Establish and improve equipment operation protocols

Required Qualifications*

  • Bachelor’s degree in Biology, Biochemistry, Biophysics or a related field
  • Knowledge of principles of transmission electron microscopy
  • Understanding of single particle approach, Cryo electron tomography is a plus
  • Excellent verbal, written and interpersonal skills with a strong customer service focus and demonstrated commitment to creating a positive work environment.
  • Highly organized, attentive to detail and accuracy, and strong record-keeping skills are essential.
  • Demonstrated ability to successfully interact with diverse groups of faculty, staff and students. 
  • Demonstrated ability to work collaboratively in a team environment as well as independently.
  • Experience in providing instruction/training to others.
  • Proven ability to adapt as priorities shift.
  • Demonstrated ability to set priorities, multi-task, handle multiple assignments and meet deadlines, and display excellent judgment while operating in a flexible and professional manner.

Desired Qualifications*

  • Master’s in Biology, Biochemistry, Biophysics or a related field
  • Hands-on experience in Cryo-EM
  • Prior experience working in an academic research setting

Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks will be performed in compliance with the Fair Credit Reporting Act.

Application Deadline

Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.