How to Apply
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
An exciting opportunity has been created for an experienced researcher to join the Alumkal Laboratory (www.ohsu.edu/alumkal-lab) that is moving from Oregon Health & Science University to the U of M Division of Hem-Onc and the Rogel Cancer Center in Ann Arbor, MI. This individual will join as a Lab Manager and work directly with Dr. Joshi Alumkal, Leader of the U of M Prostate/Genitourinary Oncology Cancer Section. He/she will be an integral member of research team whose focus is epigenetics and drug resistance in prostate cancer. Our laboratory focuses on identifying mechanisms by which key chromatin modifying enzymes and chromatin readers drive transcription of pathways that promote treatment resistance. We use genomic/epigenomic studies in prostate cancer clinical samples and prostate cancer cell line model systems and functional studies to understand this process. Our goal is to develop new, targeted treatment strategies for men with advanced prostate cancer. This individual will be responsible for managing laboratory operations, including: regulatory aspects such as IBC, IACUC, and IRB; equipment maintenance and service contracts; carrying out experiments in the laboratory, including: including mouse xenograft experiments and drug treatment, protein and RNA expression and purification from mammalian cells and bacteria, QPCR, Western blotting, reporter gene analysis, ELISA, tissue culture of mammalina cell lines and transfection. Ordering supplies, inventorying, and unpacking deliveries are also important responsibilities.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
- Performs cell culture, molecular biology techniques including:
- DNA/RNA/protein extraction, QPCR, and Western blots, etc. Performs mouse
- xenograft tumor growth experiments with castration, drug injections, drug
- gavage, tumor measurements.
- Manages day to day lab operations to include lab orders and stock lab supplies,
- maintains equipment and submission and maintenance of regulatory approvals
- (IACUC, IRB, IBC) related to our projects.
- Additional laboratory duties as assigned by PI
- Bachelor's degree (4yr) in a related field of science and 3 years or more of related experience
- Greater than 2 years working in a laboratory environment post-college.
- Strong molecular biology knowledge and skills including experience with protein expression and purification.
- Proficiency in RNA and protein purification from mammalian cells and bacteria.
- Proficiency in cloning, expression, and purification of plasmids from bacteria.
- Proficiency with mammalian cell culture.
- Experience in practical applications of molecular biology techniques, such as RT-PCR, western blotting, reporter gene analysis, and ELISA assays.
- Strong organizational and multi-tasking skills.
- Excellent teamwork and communication skills.
- Ability and willingness to learn and implement novel experimental techniques.
- Knowledge and understanding of laboratory safety and ability to work carefully with potentially harmful agents.
- Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint).
- Previous lab management skills are strongly preferred.
- Prior experience with writing and maintaining IACUC, IBC, or IRB protocols are strongly preferred.
- Rodent handling experience, especially with xenograft tumor growth experiments involving castration, injection and/or gavage treatment, and tumor measurements is strongly preferred.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.