How to Apply
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
This position is for a senior lab technician in a laboratory that focuses on investigating the biological basis of sex differences in cardiovascular diseases. The ideal candidate should have proficiency with murine tissue procurement and basic molecular biological techniques, such as RT-PCR amplification, immunoblot analysis, ELISA, and histology and be comfortable with management of a large mouse colony. Strong organizational skills are a must. The position is full-time. The laboratory director is an advanced heart failure physician-scientist with extensive training in molecular biology and engineering techniques. Additional responsibilities may include minimal work with DNA isolation from human blood, protein analyses, and training of undergraduate or medical students.
This position offers the benefits of an independent spacious location at the North Campus Research Complex which has an on-site gym and childcare. Lab personnel will meet with the PI weekly which provides opportunities for further discussion about many scientific topics, including heritable cardiomyopathy, heart failure, valvular heart disease, and strategies to elucidate the biological basis of sex differences in these cardiovascular diseases.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Develop assays and protocols for PI approval and design experimental approaches for research projects. Perform a wide range of sophisticated assays. Make significant/important contributions to various aspects of research efforts. May include troubleshooting, independent decisions and training/guidance of other lab personnel. Maintenance of large mouse colony.
Responsible for assigned daily research projects that require experience in standard molecular biology and biochemical techniques (i.e. RT-PCR, ELISA, immunoblot). Performs tissue culture procedures (isolating primary cells for culture and taking care of different primary cell lines), media and solution preparations for tissue culture, basic molecular biology such as DNA, RNA, protein extraction, amplification by PCR. Procures murine tissue for experiments. Tissue sectioning, IHC and IF helpful. Perform laboratory experiments by following common protocols or with instruction. Run lab tests and complete measurements assigned. Collect project data. Identify and resolves common problems involved in routine research assays. Utilize specialized knowledge to interpret results, e.g. reading controls, evaluate results. Gain problem solving skills through progressive training, understanding of the research, and experience. Use scientific knowledge and lab experience to make judgments and decisions. Understands the role of senior lab members and accepts constructive guidance. Increases own skill base and knowledge of lab research and relevant assays. Applies basic science knowledge to learn new techniques/methods. Works independently.
Maintaining mouse colony including breeding, genotyping and record keeping.
Prepare, test and maintain standard laboratory equipment. Perform related laboratory maintenance, monitoring inventory of supplies, cleaning equipment. Train users in standard equipment operation and routine lab techniques and procedures. Teach/train students, and new technicians in the lab as needed. Guide, direct and facilitate problem solving for entry-level lab members on day-to-day problems with more challenging research assays. Facilitate communication with collaborating labs.
Make scientific contribution to protocol development, efficiency, and productivity. Collaborate in development of new techniques and instruments. Apply published research methods to current experimental work by investigating published protocols and discussing them with PI. May scientifically contribute to writing of manuscripts and grants. Process analyzed data into figures for scientific publications.
Education: Bachelor’s degree in biology, chemistry or related field.
Experience: At least two years laboratory experience in a comparable laboratory performing relevant techniques. Master’s degree, with related graduate research, may substitute for experience.
Physical Requirements: Reaching by extending hand(s) or arm(s) in any direction; finger dexterity to manipulate objects with fingers rather than with whole hand or arm. Communication skills using the spoken word; Ability to see and hear within normal parameters; lift, carry, move supplies, computers, glassware, etc. Ability to move about workspace.
Education: Master’s degree in Biomedical Sciences or related field.
Experience: Mouse work experience, histology experience, myocyte and nonmyocyte isolation from neonatal and adult murine hearts.
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Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
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The University of Michigan is an equal opportunity/affirmative action employer.