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The Barmada Laboratory is currently seeking a Research Laboratory Specialist Intermediate to work on a focused research project in basic/translational neuroscience utilizing human induced pluripotent stem cells (iPSCs). The overarching goals of the project are to: (1) discover how the cellular pathway of autophagy is dysregulated by mutations in neurologic disease; (2) determine the connection between autophagy dysregulation and toxicity for vulnerable neuronal populations; and (3) identify novel ways to restore autophagy function in disease and are amenable for therapeutic design. The successful candidate will work alongside Dr. Chua, Dr. Barmada, and existing lab members to design, perform, and interpret experiments with these objectives in mind.
*This position is term limited to 2 years.*
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What Benefits can you Look Forward to?
- Excellent medical, dental and vision coverage effective on your very first day
- Retirement Savings Opportunities
In collaboration with research staff and the Principle Investigator this individual will participate as a uniquely skilled contributor and lead specialist on multiple research experiments serving as an expert in the field of neurodegenerative diseases. He or she will engage in the engineering of new iPSC lines and their differentiation into multiple cell types, use of CRISPR/Cas9 for gene editing in iPSCs, and use a combination of techniques to study autophagy in these cells — including but not limited to fluorescence microscopy, qRT-PCR, Western blot, and immunocytochemistry. Orientations will be provided for the laboratory’s equipment operation and common research techniques.
Furthermore, this individual will: (i) consult with end users to refine or adapt methodologies to fit specific experiment requirements and collaborate in the development of new techniques; (ii) coordinate data collection, screening, and verification; (iii) lead periodic research discussions and project subcommittee meetings; (iv) analyze data, and interpret and implement research methodology based on the outcomes; (v) adapt instrumentation, equipment, and research models for data acquisition and analysis; (vi) investigate, modify and apply new procedures, techniques, or emerging technologies and integrate new findings; (vii) compose results for inclusion in published manuscripts and grant proposals; (viii) collaborate with researchers to achieve short and long range plans; (ix) maintain direct and daily oversight over data collection and instrument use; (x) monitor integrity of data collection and ensure compliant use of equipment, protocols, and procedures; (xi) review and critique other researchers; (xii) analyze, compare and evaluate various courses of action, making decisions on matters of significance, free from immediate direction, within the scope of their responsibilities. It is also expected that this specialist will assist or provide feedback to the composition of manuscripts, chapters, or research abstracts while collaborating with other researchers to publish their research findings.
Requirements include a Master's degree in molecular biology, neuroscience, biochemistry, or a related discipline and 4 years' experience. The qualified incumbent will be expected to be experienced in basic and advanced molecular biology and cell biology techniques including gene cloning, protein isolation, DNA/RNA extraction and purification, quantitative real-time PCR, sequencing, primer design and mutagenesis using PCR, fluorescence microscopy, and tissue culturing. A large part of the work for this project involves culturing iPSCs and iPSC-derived neurons, and incumbents will be expected to be proficient in iPSC maintenance, differentiation, and transfection. The incumbent will also be expected to manage and devise novel processing algorithms required for image-based data extraction. Applicants should be reliable and able to work congenially alongside a group of equally hard-working scientists.
PhD in molecular biology, neuroscience, biochemistry, or a related discipline.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
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The University of Michigan is an equal opportunity/affirmative action employer.