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How to Apply

Please provide a cover letter that addresses your specific interest in this position and outline relevant skills and experience. Please also include a resume and the names of three references.

 

For more information, contact:

 

Dr. Kenichi Kuroda, kkuroda@umich.edu

website: https://media.dent.umich.edu/labs/kuroda/

 

Job Summary

A postdoctoral fellow position is available to conduct microbiological studies proposed for two funded projects: (1) new polymer-drug conjugates to treat drug-resistant bacteria and (2) new polymeric materials to eliminate bacterial biofilms. 

Research projects:

Project 1 - The goal of the project funded by the National Science Foundation is to develop new polymer-antibiotic conjugates that enable targeted delivery of antibiotic molecules to the binding sites in bacteria to overcome drug resistance in Gram-negative bacteria. This study involves the design and synthesis of the conjugates (polymer synthesis and characterization), evaluation of antibiotic efficacy (bacteria growth inhibition assay, time-killing assay, cytotoxicity assessment using human cells), and identification of the antimicrobial and delivery mechanisms (cell wall synthesis inhibition assay, cell membrane permeation assay, cell wall/membrane binding assay by microscopy using bacterial cells and spheroplasts).

 

Project 2 – The goal of the project supported by the National Institute of Dental and Craniofacial Research is to develop a new polymer-based strategy to control oral biofilms. We will develop pH-responsive synthetic polymers that can target acidic cariogenic biofilms and remove them by altering the mechanical properties of the biofilm matrix. This study involves the design and synthesis of polymers (polymer synthesis and characterization), evaluation of bactericidal efficacy and therapeutic index (bactericidal assay, in vitro cytotoxicity assay using human oral tissue cells), and in vitro investigations on eradication of acidogenic oral biofilms and changes in bacterial flora (biofilm viability assays, biofilm imaging by fluorescence microscopy, microbiome analysis).

Duties: The successful candidate will work with other lab members and collaborators to conduct microbiological studies proposed for these two projects. The candidate must be highly motivated with strong research capabilities and the ability to design and carry out experiments with a high level of independence. This individual will also assist the PI in training new lab members, manage lab equipment and inventories, and write research manuscripts and documents.

Qualifications: The candidate must have a PhD or equivalent degree in microbiology or molecular biology with experience relevant to these two projects. Excellent verbal and written communication skills in English are required. A strong publication record in peer-reviewed journals is desired.

Mission Statement

MDentistry: advancing health through education, service, research and discovery.

MDentistry Core Values: Compassion, Leadership, Excellence, Responsibility, Trust, Creativity, and Inclusion.

The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future. The University of Michigan is committed to foster learning, creativity and productivity, and to support the vigorous exchange of ideas and information, not only in the classroom but in the workplace by:

  • Creating a work environment in which people treat each other with respect and dignity, regardless of roles, responsibilities or differences.
  • Providing support, direction and resources enabling us to accomplish the responsibilities of our jobs and to reach the goals that are set for professional and personal growth.

Work Locations

This position is located at the School of Dentistry at 1011 N. University Avenue, Ann Arbor, MI 48109-1078. 

Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks will be performed in compliance with the Fair Credit Reporting Act.

Application Deadline

Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.