The University of Michigan College of Pharmacy has a full-time opening for a research lab specialist associate in its Pharmacokinetics and Mass Spectrometry Core Facility (PKMS, www.pkcore.org). PKMS is a shared core resource facility in UM, and serves the scientific research community at UM and beyond.
- Microsomal stability testing using LC-MS: Will develop, design and conduct liver microsomal stability experiments in line with the overall research plan, review progress and evaluate results (with supervision from the PI and senior members of the laboratory).
- Quantitative LC-MS analysis of compounds in biological matrix of preclinical and clinical samples: Will be a key contributor to multi-disciplinary project teams supporting early discovery programs or clinical trial through establishing LCMS-based assays to enable the discovery and development of high-quality small molecule therapeutics.
- Metabolite identification using LC-MS/MS in microsomal incubation and in vivo biological matrix: Will conduct mass-based assay to determine the molecular weight, elemental composition, and proposed structures of a drug compound’s metabolites. It will involve multiple different method on analysis of data, and interpret and implement research methodology.
- Preclinical and clinical pharmacokinetic analysis: Will review and study the data from preclinical and clinical quantitative analysis and interpretation of multi-source data to better characterize and differentiate compounds, thus adding value and enhancing the research.
- Clinical biological sample preparation including plasma and biological fluids: Will entail establishing robust sample preparation protocols and developing targeted and untargeted MS acquisition methods suited for quantitative analysis of small molecular analytes within complex mixtures derived from biological matrices.
- Independent preparation of study reports: Will make a data analysis for experiment results in final report.
- BS in Chemistry (MS preferred)
- LC-MS skill, knowledge, and experience for small molecules
- 2-3 years experience with liquid chromotography and mass-spectrometry
- Hands on experience with dosing and sample collection on animals.
- Strong oral and written communication skills.
- Ability to work closely with others in a small team setting.
Please note this position will be term limited through 12/31/2023. Position may be extended dependent upon funding.
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Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
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The University of Michigan is an equal opportunity/affirmative action employer.