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A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.


Job Summary

The Center for Structural Biology (CSB) within the Life Sciences Institute is looking for an experienced crystallographer to advance the research objectives of principal investigators in a wide variety of basic science fields and drug development. The CSB includes: a high-throughput cloning and expression laboratory for protein engineering; protein expression and purification facilities for small- and large-scale protein production; macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules; and x-ray facilities with membership access to high energy synchotron radiation (LS-CAT beam-lines at the Argonne National Laboratory). Staff scientists in the CSB work under the direction of the Managing Director, Dr. Jeanne A. Stuckey, and will work in collaboration with members of her lab and researchers who use the facilities.

Mission Statement

Our mission at the Life Sciences Institute is to advance the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health.

For additional information on the Life Sciences Institute, please go to:

For additional information on the CSB:, please go to:


Experimental responsibilities will include:

  • Design and execute experiments in collaboration with others
  • Help coordinate and manage projects
  • Perform quantitative analyses and communicate findings through reports and summaries
  • Perform innovative research resulting in co- and lead-authored publications on structures of therapeutic and biological importance
  • Facilitate the utilization of protein structures by providing expert interpretation to enhance the design efforts of the medicinal and computational chemists
  • Execute your grasp of modern cloning, expression and purification methodologies
  • Develop novel crystallization techniques
  • Perform crystallization screens
  • Solve structures

Non-experimental responsibilities will include:

  • Maintain clear laboratory notebooks
  • Provide detailed documentation so experiments can be replicated
  • Follow laboratory best practices for safety and quality

Required Qualifications*

  • Ph.D. in structural biology, biophysics, biochemistry or related discipline
  • Minimum of 1 year post-doctoral work experience
  • Minimum of 3 years crystallography experience in construct design, structure determination and interpretation
  • Prior experience working in a collaborative environment

Desired Qualifications*

  • Minimum of 1 year experience in biophysical techniques that assess direct protein-ligand binding (e.g., isothermal calorimetry, mass spectrometry, bio-layer    interferometry,  fluorescence polarization, NMR)
  • Minimum of 1 year experience in molecular dynamics simulations
  • Minimum of 1 year experience in ligand design or modeling

Additional Information

Benefits at the University of Michigan

In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:

  • Generous time off
  • A retirement plan that provides two-for-one matching contributions
  • Many choices for comprehensive health insurance
  • Dental, Vision and Legal Insurance
  • Life insurance
  • Long-term disability coverage
  • Flexible spending accounts for healthcare and dependent care expenses

Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks.  Background checks are performed in compliance with the Fair Credit Reporting Act.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.