How to Apply
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The Kim and Sisson labs are investigating the pathogenesis of pulmonary fibrosis which is a devastating disorder with limited medical therapy large due to a poor understanding of the mechansims of disease. We have funding and prelimary data to support studying a novel pathway in which alveolar epithelial cell (AEC2) injury/apoptosis results in a coordinated response in which the elaboration of CCL12 (the primary murine homolog of human CCL2) from injured AECs recruits monocyte-derived macrophages to the alveolar space where they engulf oxidized phospholipid-rich apoptotic AEC2s. In turn, the accumulation of oxidized phospholipid induces a phenotypic switch in the macrophage that is a critical driver of fibrosis. Our labs utilyze a comprehensive array of in vivo and in vitro experiments. In vitro assays using primary isolated murine cells and primary human cells from normal and diseased lung tissue for detailed biochemical and mechanistic analysis. For in vivo studies we have generated several novel mouse models including mice with AEC specific death (using AEC-promoter specific expression of diphtheria toxin receptor), floxed CCL12 mice enabling cell type specific deletion and mice deficient in LPLA2 the primary enzyme involved in degradation of surfactant phospholipid. In vivo studies include generation of bone marrow chimera, lineage tracing, and assays of fibrosis. This project has very high enthusiasm in the scientific community with a R01 proposal scoring at the 5th pertentile in a recent NIH study section. In addition to co-mentorship by Dr. Kim and Dr. Sisson, post-doctoral personnel can expect to work in a highly collaborative environment with several co-investigators.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Why Join Michigan Medicine?
Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world’s most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.
What Benefits can you Look Forward to?
- Excellent medical, dental and vision coverage effective on your very first day
- Retirement Savings Opportunities
Performing research studies and data analysis - molecular biology and immunology assays (e.g., ELISA, isolation of RNA and PCR, flow cytometry)
- animal (mouse) studies including survival surgeries and monitoring
Preparing manuscripts for publication and grant submissions; other scholarly activities (e.g., presentations, manuscript reviews, etc.; to be determined with PI)
Share in general maintenance of lab equipment and inventory, lab cleanliness, restocking of solutions, etc. as relevant to own research
Maintaining training and compliance with research regulations and policies, including assisting with enforcing lab safety practices and prepping for inspections
Teaching and sharing expertise with other lab members, participating in lab meetings and conferences
PhD in biological sciences, chemistry, or related scientific field
Experience with animal models
Experience handling mice desired but not required.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.