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How to Apply

Submit a cover letter as first page of CV.  Direct inquiries to Dr. Lei Yin or Xin Tong at or

Job Summary

NIH-funded postdoctoral positions are available immediately (Oct. 2021) in the Yin/Tong laboratory at the department of Molecular and Integrative Physiology at the University of Michigan Medical School to study molecular and cellular mechanisms involved in the onset and development of diet induced Non-Alcoholic Steatohepatitis (NASH). To dissect mechanism, a variety of experimental approaches are employed including mouse gene targeting, biochemical and molecular cell biological analyses of hepatocyte and hepatic stellate cells, co-culture system, and genetic analysis of human samples. 

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Who We Are

The Yin/Tong lab is located at a newly established Elizabeth Weiser Caswell Diabetes Center at north campus of University of Michigan.  The University of Michigan is committed to diversity, equity and inclusion and has a very strong track record in the training and mentoring of postdoctoral fellows.

Relevant recent publications:
Zhang D, Tong X, Gupta N, Omary B, Rui L, Lin JD, Yin L. The lipogenic factor ChREBP mediates fructose-induced metabolic adaptions to prevent hepatotoxicity. Journal Clinical Investigation, 2017 127(7):2855-2867

Tong X, Zhang D, Shabandri O, Charney N, Yang MC, Stamper K, Jin E, Yin L. High fructose diet promotes liver De Novo lipogenesis pathway by stabilizing ChREBP via DDB1-mediated CRY1 degradation. Metabolism, 2020 107: 154222

Zhang D, Wang S, Ospina E, Shanbandrd O, Lank D, Akakpo J, Zhao Z, Yang M, Wu J,
Jaeschke H, Saha P, Tong X and Yin L.: Acetaminophen-induced hepatoxicity mainly via activating the ChREBPa-FGF21 axis in mice Hepatology Communication 2021 0(0): 1-17 (In Press)

Yang M, Zhang D, Zhao Z, Sit J, Saint-Sume M, Shabandri O, Zhang K, Yin L, Tong X.:
Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet induced ER stress FASEB J 2020 34(10): 13533-13547

Zhang D, Tong X, Nelson BB, Jin E, Sit J, Charney N, Yang M, Omary MB, Yin L.: The hepatic BMAL1 /AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARa pathway Hepatology 2018 68(3): 883-896

Tong X, Zhang D, Charney N, Jin E, VanDommelen K, Stamper K, Gupta N, Saldate J,
Yin L.: DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver Diabetes 2017 66(10): 2571-258

Required Qualifications*

Interested candidates should possess PhD and /or MD degrees and experience in one or more of these areas (mouse gene targeting, biochemical and molecular cell biological analyses of hepatocyte and hepatic stellate cells, co-culture system, and genetic analysis of human samples).

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.


U-M COVID-19 Vaccination Policy

COVID-19 vaccinations are now required for all University of Michigan students, faculty and staff across all three campuses, including Michigan Medicine.  This includes those working or learning remotely.  More information on this policy is available on the Campus Blueprint website or the U-M Dearborn and U-M Flint websites.