How to Apply
Submit a cover letter as first page of CV. Direct inquiries to Dr. Lei Yin or Xin Tong at .email@example.com or firstname.lastname@example.org.
NIH-funded postdoctoral positions are available immediately (Oct. 2021) in the Yin/Tong laboratory at the department of Molecular and Integrative Physiology at the University of Michigan Medical School to study molecular and cellular mechanisms involved in the onset and development of diet induced Non-Alcoholic Steatohepatitis (NASH). To dissect mechanism, a variety of experimental approaches are employed including mouse gene targeting, biochemical and molecular cell biological analyses of hepatocyte and hepatic stellate cells, co-culture system, and genetic analysis of human samples.
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Who We Are
The Yin/Tong lab is located at a newly established Elizabeth Weiser Caswell Diabetes Center at north campus of University of Michigan. The University of Michigan is committed to diversity, equity and inclusion and has a very strong track record in the training and mentoring of postdoctoral fellows.
Relevant recent publications:
Zhang D, Tong X, Gupta N, Omary B, Rui L, Lin JD, Yin L. The lipogenic factor ChREBP mediates fructose-induced metabolic adaptions to prevent hepatotoxicity. Journal Clinical Investigation, 2017 127(7):2855-2867
Tong X, Zhang D, Shabandri O, Charney N, Yang MC, Stamper K, Jin E, Yin L. High fructose diet promotes liver De Novo lipogenesis pathway by stabilizing ChREBP via DDB1-mediated CRY1 degradation. Metabolism, 2020 107: 154222
Zhang D, Wang S, Ospina E, Shanbandrd O, Lank D, Akakpo J, Zhao Z, Yang M, Wu J,
Jaeschke H, Saha P, Tong X and Yin L.: Acetaminophen-induced hepatoxicity mainly via activating the ChREBPa-FGF21 axis in mice Hepatology Communication 2021 0(0): 1-17 (In Press)
Yang M, Zhang D, Zhao Z, Sit J, Saint-Sume M, Shabandri O, Zhang K, Yin L, Tong X.:
Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet induced ER stress FASEB J 2020 34(10): 13533-13547
Zhang D, Tong X, Nelson BB, Jin E, Sit J, Charney N, Yang M, Omary MB, Yin L.: The hepatic BMAL1 /AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARa pathway Hepatology 2018 68(3): 883-896
Tong X, Zhang D, Charney N, Jin E, VanDommelen K, Stamper K, Gupta N, Saldate J,
Yin L.: DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver Diabetes 2017 66(10): 2571-258
Interested candidates should possess PhD and /or MD degrees and experience in one or more of these areas (mouse gene targeting, biochemical and molecular cell biological analyses of hepatocyte and hepatic stellate cells, co-culture system, and genetic analysis of human samples).
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