How to Apply
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
Summary
The Kaczorowski lab at the University of Michigan is recruiting post-doctoral scholars to study novel in vitro 2D and 3D cell culture systems for understanding the molecular mechanisms underlying cellular resilience to Alzheimer’s disease, as well as applications for screening drug targets predicted to promote resilience Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neurons | bioRxiv. The successful candidate will have strong experience in cellular biology, will culture and maintain primary and secondary cell lines. Cellular phenotypes of interest include inflammation, protein homeostasis, cellular senescence, mitochondrial functioning, cellular energetics (NAD+/NADH) and lysosomal functioning. Techniques utilized will include various molecular assays, viral transfections, live cell imaging, immunocytochemical staining, neuronal functioning, gene expression, protein expression, computational biology, developing/optimizing derivation protocols from stem cells and general cell culturing practices. The Kaczorowski Lab team values excellence, integrity, diversity, impact, and kindness - and we are looking postdoctoral trainees and research scientists who are enthusiastic, creative, and experienced in primary cell culture.
The Kaczorowski lab is in the Department of Neurology at the University of Michigan Medical School located in Ann Arbor, Michigan. The city is ranked among the top 10 places to live in the U.S, with a community that is culturally rich, diverse, pedestrian and bike friendly. The Michigan Neuroscience Institute (MNI) continues to be a leader in innovative, collaborative, and visionary research in the areas of brain science and brain impacting diseases. MNI’s cross-disciplinary research portfolio reflects the full range of basic and translational projects from molecular analyses to animal models to human applications. More information about the Kaczorowski lab can be found at http://kaczorowski.lab.medicine.umich.edu or on Twitter @KaczorowskiLab.
Responsibilities*
The successful candidate will be able to plan, develop, execute, and analyze an independent research project in the context of a supportive lab and institutional environment. In addition, they will supervise and help train graduate students, undergraduate research assistants and junior technicians in the lab. We are looking for someone that has the aptitude to learn new techniques, works well with others, and possesses strong critical thinking skills.
- Generating in vitro 2D and 3D cultures of neurons, astrocytes and microglia derived from both genetically diverse mouse embryonic stem cells (mESCs) and human induced pluripotent stem cells (hiPSCs) isolated from patients with Alzheimer’s disease (AD).
- Molecular assays, viral transfections, live cell imaging, immunocytochemical staining, neuronal functioning, gene expression, protein expression, and computational biology.
- Maestro multi-well microelectrode array (MEA) plate utilization to quantify cellular electrical network information.
- Developing/optimizing derivation protocols from stem cells and general cell culturing practices.
- Help maintain lab organization and record all information in laboratory notebook.
- Maintain organization of lab protocols, equipment operation and standard techniques.
- Present data and plans for new experiments during laboratory meetings.
- Collaborate with colleagues to develop and achieve short- and long-range plans.
- Assists with the creation of posters, manuscripts, and presentations for scientific meetings and/or grant submissions.
- Guide and mentor graduate or undergraduate students, including participation in training to improve these skills as needed.
- Provides other support to the program as directed.
Required Qualifications*
• Education: Must possess either a Ph.D in biological or related sciences field, or a professional doctorate (e.g. M.D., DD.S., D.V.M).
Desired Qualifications*
- Exceptional verbal and written communication skills.
- Experience with immunocytochemistry, high-throughput high-content assays, phenotypic screening, and assays using complex disease cellular models.
- Understanding of cellular phenotypes of relating to inflammation, protein homeostasis, cellular senescence, mitochondrial functioning, cellular energetics (NAD+/NADH) and lysosomal functioning.
- Experience with statistical analysis and interprets and evaluates results and compiles data for peer and PI review.
Background Screening
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Application Deadline
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
Vaccine Requirements
COVID-19 vaccinations are required for all students, faculty and staff working in the following areas: Michigan Medicine including the Medical School, Dental School, University Health Service or the Mary A. Rackham Institute. This includes those working remotely and temporary workers. More information on this new policy is available on the U-M Health Response.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.