Summary
The Grohar Lab focuses on developing and clinically translating novel small molecule therapies for the treatment of pediatric solid tumors. A number of pediatric solid tumors have clear oncogenic driver mutations that are considered by many to be "undruggable." The lab has primarily focused on Ewing sarcoma and the development of therapies that target the EWS-FLI1 transcription factor. More recently, we have extended our focus to other solid tumors with the goal of better understanding therapeutic vulnerabilities at the interface of transcription and epigenetics. We have a number of compounds in various stages of clinical development including a clinical trial based on our laboratory work that is actively accruing patients. We employ high throughput genetic and chemical screens to identify novel targets and compounds, molecular pharmacology to understand the mechanism of action, and a variety of next-generation sequencing assays to delineate the effects genome-wide.
Responsibilities*
- Performs routine tests / experiments under the direction of principal investigator, supervisor or
- Performs research procedures on experimental samples as directed
- Records and checks experiments/ results for completeness and accuracy
- Performs calculations and maintains appropriate log and lab notebooks
- Performs tasks that require familiarity with fundamental techniques and lab equipment
- May assist with planning specific research protocols and procedures
- Maintains office, lab area, solutions, reagents, supplies and equipment, disposes of specimens,
- Assists lab manager in care and maintenance of lab equipment
- May coordinate schedules of tests and procedures
- Attends seminars and presents data in group lab meetings to expand knowledge of research and
laboratory techniques - Records results, organizes data and maintains lab notebook in an organized manner
- Compiles and helps analyze data, prepares charts, graphs, and results of studies as directed
- Conducts literary searches as directed
Required Qualifications*
Intermediate: HS Diploma or Assoc. Degree and 1-3 years' experience required.
Associate: HS Diploma or Assoc. Degree and 0-1 year experience required.
Skills and Abilities
- Excellent verbal and written communications skills
- Excellent organizational skills
- Solid critical thinking / problem-solving skills
- Solid analytical skills
Desired Qualifications*
Bachelor?s Degree preferred.
Underfill Statement
This position may be underfilled at a lower classification depending on the qualifications of the selected candidate.
Background Screening
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Application Deadline
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.