How to Apply
The Castro/Lowenstein Laboratory within the Department of Neurosurgery at the University of Michigan Medical School, is pleased to accept Dr. Xiangdong Yin, who is a PKU-Scholar as a trainee to join an exciting and productive research team focused on elucidating the molecular and mechanistic aspects which underlie brain tumor growth, invasion, and the response to novel immune mediated therapeutics. The applicant will be engaged in a project that will study the molecular and cellular mechanisms involved in tumor progression; the role of the extracellular matrix on tumor growth and invasion; the mechanisms which underpin immune mediated gene therapies, leading to tumor regression and anti-glioma immunological memory to prevent recurrences. The project will also utilize state-of-the-art ?omics? technologies such as Single Cell RNASeq, ChIP-Seq, ATAC-Seq, as well as advanced Bioinformatics. The candidate will also learn immunological functional assays and 3D-multiplex immunohistochemistry to uncover cell-cell interactions and immune neighborhoods in the tumor microenvironment. The project has a strong translational component focusing on the development and implementation of novel therapeutic approaches in human clinical trials for brain cancer; these include gene therapy strategies, small molecules, and nanotechnologies. The candidate will have the opportunity to learn the mechanisms of action of novel gene therapy and combination therapies and explore ways that our team will implement to translate the research into novel Phase I clinical trials for GBM
How to Apply
Please submit your UM Application and your CV or resume.
Mission Statement
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Required Qualifications*
- PhD in a recognized field of science related to the position, potentially supplemented by at least 2 years of experience in a research setting relevant to the position
- A strong work ethic
- The ability to work independently combined with a willingness to work in a highly interactive and collegial group.
- The applicant is expected to provide significant input into the development of experiments, procedures and research design as well as to assist the principal investigator in determining research goals.
Modes of Work
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.
U-M EEO Statement
The University of Michigan is an equal employment opportunity employer.