RESEARCH INVESTIGATOR

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Job Summary

This position will work in a lab that studies organ preservation, mitochondrial biology, and cardioprotection, providing a roadmap for next-generation preservation strategies, particularly in transplantation, advanced cardiovascular therapies, and translational science. 

The candidate will investigate the role of Brd4-S in modulating chromatin configuration during cardiac preservation.   He/She will further investigate how donor heart age, as an intrinsic biological factor, contributes to the primary graft dysfunction (PGD) after transplant.   

The candidate will be responsible for the design and execution of experimental work, data analysis and their written records. Attendance and presence at internal, national and international meetings will be a key part of this role.  Progress towards independent research is expected and papers published in in top scientific journals.

Required Qualifications*

• Ph.D. and a minimum of 8 years' experience in basic and translational research
• A minimum of 15 publications in peer-reviewed journals and publications.
• Expertise in the roles of Brd4 and 3D chromatin architecture remodeling and aged donor heart preservation.
• Research interests in the following:
  • metabolism-modulated Flot1 post-translational modifications affecting donor heart
    preservation quality
  • deciphering the interaction of metabolic reprogramming and chromatin regulation during ischemia-reperfusion
    injury in heart and liver
  • elucidating the epigenetic mechanism by which histone modifications regulate cardiac regeneration
    and repair in heart failure.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Background Screening

University of Michigan Health System conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act.

U-M EEO Statement

The University of Michigan is an equal employment opportunity employer.