Mission Statement
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job Summary
The laboratory of Dr. Celina Kleer in the University of Michigan Department of Pathology is seeking a highly motivated postdoctoral research fellow to investigate the cellular and molecular mechanisms of breast cancer invasion and metastasis, with particular emphasis on the tumor microenvironment. The research will focus on EZH2 signaling and interactions among tumor, stromal, and immune cells.
Responsibilities*
Design, conduct, analyze, and troubleshoot independent studies of EZH2 and other related protein signaling in breast cancer invasion, metastasis, and the tumor microenvironment.
Perform cellular and molecular biology experiments and studies of the stroma and immune microenvironment
Conduct mouse mammary tumor and metastasis studies and implement high-throughput spatial methods.
Review relevant literature, maintain accurate records, interpret findings, and present results.
Prepare abstracts, manuscripts, presentations, and contributions to grant applications.
Collaborate with laboratory members and mentor undergraduate researchers.
Support laboratory operations, including protocol development, reagent ordering, and research compliance.
Required Qualifications*
Ph.D., M.D./Ph.D., or equivalent doctoral degree in cancer biology, cell biology, molecular biology, immunology, pathology, or a related field by the start date.
Proficiency in mammalian cell culture and standard cellular and molecular biology techniques (e.g. transductions, immunoprecipitation, flow cytometry, functional assays, western blot, qRT-PCR)
Ability to design, conduct, analyze, troubleshoot, and document experiments independently.
Demonstrated scholarly achievement through publications, presentations, awards, or significant research contributions.
Strong written and oral scientific communication, and collaboration skills
Interest or experience in mentoring undergraduate students.
Desired Qualifications*
Experience in studies of the tumor immune microenvironment and/or tumor-stroma interactions.
Experience in breast cancer biology.
Experience with mouse tumor models, including mammary gland inoculation and metastasis assays.
Experience preparing manuscripts, abstracts, fellowship applications, or grant proposals.
Why Join Michigan Medicine?
Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.
What Benefits can you Look Forward to?
Excellent medical, dental and vision coverage effective on your very first day
Modes of Work
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.
Additional Information
The fellow will receive mentorship in experimental design, scientific writing, manuscript preparation, grant and fellowship applications, conference presentations, and career development. The position offers opportunities to lead research projects, collaborate across disciplines, mentor junior researchers, and develop an independent scientific profile.
Applicants should submit the following:
Curriculum vitae
Cover letter describing research experience, technical skills, interest in the position, and career goals
Contact information for three professional references
Up to three representative publications or manuscripts
Background Screening
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
U-M EEO Statement
The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.