Job Summary
The Prensner laboratory at the Chad Carr ? Pediatric Brain Tumor Center is looking for an exceptional candidate for a unique position. This position affords the exciting opportunity to be part of a research effort aiming to dissect the genomic basis of cancer and its therapeutic implications.
Responsibilities*
OVERALL RESPONSIBILITY
The successful candidate will play a key role in advancing projects and hypotheses on the role of the dark proteome in cancer, as part of the Cancer Grand Challenges team ILLUMINE. The work will also liaise with the dark proteome in non-cancer samples through the GENCODE consortium.
The successful candidate will advance cancer-related work around our active projects in:
Non-canonical open reading frames
RNA translational control
RNA diagnostics
The successful candidate will be expected to conduct wet-lab molecular biology and tissue culture experiments. Knowledge of bioinformatic analyses is considered a strength.
The candidate is expected to work independently on a daily basis, with regularly scheduled meetings with the Principal Investigator.
PRINCIPAL DUTIES AND RESPONSIBILITIES
Initiate and lead sequencing process improvement efforts
Onboard and optimize emerging sequencing technologies through working directly with vendors or other specialized experts.
Advance research projects with a multi-omic focus, employing ribosome profiling, RNA-sequencing and epitranscriptomic profiling.
Execute experiments for tissue culture, in vitro bioassays, and small molecule treatments.
Operates and maintains laboratory equipment to complete investigations.Documents, compiles, and analyzes experimental data. Reports data to supervisor in oral and written reports.
Attends team meetings and contributes to experimental planning.
Nurture a lab culture that is collaborative, supportive and scientifically adventurous.
Maintain and develop collaborations to advance the scientific work.
Other related tasks as required.
Required Qualifications*
Bachelor degree in the life sciences.
5-6 years of research experience.
Desired Qualifications*
Master's or Doctoral degree in the life sciences.
Prior experience with mammalian tissue culture, DNA/RNA molecular assays, protein biology, and -omics is desired
Experience with molecular techniques such as PCR, RNA extraction and DNA extraction, is required
Exceptional organizational and critical thinking skills, lab notebook practices and attention to detail are critically essential.
Excellent communication skills and the ability to interact with all levels of staff and with external contacts are needed.
Ability to handle a variety of tasks in a fast-paced environment, large complex experiments, and large data sets, all of which demand great attention to detail.
Basic computational skills with sequencing data analysis in R is preferred.
Ability and eagerness to learn in a self-motivating environment.
Modes of Work
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.
Additional Information
PRENSNER LAB ENVIRONMENT
The Prensner Lab seeks to create a lab culture based on respect, integrity, perseverance, and fun. We aspire to be creative and collaborative scientists who are societally-engaged. We regularly collaborate with labs both nationally and globally. We welcome applicants of all kinds.
ABOUT THE CHAD CARR - PEDIATRIC BRAIN TUMOR CENTER
The Chad Carr - Pediatric Brain Tumor Center is a nationally recognized center of excellence for research and clinical care for children with brain cancers. Since 2018, investigators at the Chad Carr - Pediatric Brain Tumor Center have been awarded over $22 million in NIH or DOD funding, with over 125 scientific papers published. The Center hosts 2 dozen clinical trials for patients, participates in numerous cooperative clinical trials and tissue biobanks, and has been a destination center for referrals for patients from across the US.
ABOUT THE UNIVERSITY OF MICHIGAN
The University of Michigan at Ann Arbor is one of the world's premier research universities, consistently voted as one of the two top public research universities in the US and one of the top 25 global research institutions. It ranks third in funding for research and is one of the top five institutions for producing academic faculty. The nationally recognized medical school, cancer center, and basic science departments afford close interactions with top academic teams of diverse skillsets.
Background Screening
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.
Application Deadline
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled any time after the minimum posting period has ended.
U-M EEO Statement
The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.